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Diabetes mellitus, which is a complication of obesity, can activate satellite glial cells of the supracervical ganglia through P2Y receptors, resulting in increased expression of pro-inflammatory cytokines such as IL-1, and causing oxidative damage to the autonomic nerves such as via an inflammatory response (111, 112) ( Figure 2 )

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Non-alcoholic fatty liver disease in an area of southern Italy: Main clinical, histological, and pathophysiological aspects

The intensity of the symptoms can vary as well, depending on the severity and duration of the condition

Hijazi, BM-W

In summary, we observed a signature of hepatic ferroptosis in a subgroup of MASLD patients (in 2050% of subjects) using machine learning